Promethazine blocks dopaminergic (D2) receptors in the chemoreceptor trigger zone near the fourth ventricle. Most of these medications are best when used sparingly , when needed. Hobbs and John J. Promethazine-containing products are abused for their sedative effects and to achieve a state of delirium. Phenergan is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections. I think it acts as a sort of strong antihistamine. Promethazine (trade name Phenergan) is a first generation antihistamine, but it’s phenergan sedative also used for its sedative and antiemetic (motion sickness treatment) properties. Phenergan is a known sedative and may cause drowsiness in some people. This effect of the medicine is used to produce sedation before minor procedures or surgery, and can also be used to provide short-term help for people with sleeping difficulties (insomnia). I always got restful sleep from it, but I never tried it alone. Phenergan Injection may increase, prolong, or intensify the sedative action of central-nervous-system depressants, such as alcohol, sedative/hypnotics (including barbiturates), general anesthetics, narcotics, narcotic analgesics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced. It may help with some symptoms associated with the common cold. This synthetic drug is also a powerful sedative, which is why it is often added to sleep aids and medications that cause drowsiness like cough syrup or cold medicine Sedatives are drugs used to relieve anxiety and help you relax. Phenergan (promethazine) is used as a sedative and hypnotic during anesthesia and as a premedication for anesthesia. sedative or hypnotic. Studies show that promethazine is as effective as ondansetron (Zofran) in PONV. P roblem: Promethazine (Phenergan, Wyeth) is a commonly used injectable product that possesses antihistamine, sedative, anti-motion sickness, and anti-emetic effects.The drug is also a known vesicant that is highly caustic to the intima of blood vessels and surrounding tissue. Sarmento, et al.,. Promethazine is a first-generation antihistamine. Children 2-5 years: Three or four 5ml spoonfuls as a single dose at night time; Children 5-10 years: Four or five 5ml spoonfuls as a single dose at night time. In contrast, significant concerns have been raised about the use of prometh-azine in infants and young children.8’9 Case reports have linked promethazine to apneic episodes in this age group. Droperidol Is frequently used in the treatment of ambulatory patients. Promethazine should not be used in children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. Alcohol should be avoided during treatment. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long. It can reduce nausea and vomiting by action on the CTZ. Phenergan will enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative or hypnotic. One in 5 families admits to using sedative drugs, including Phenergan, on their children for a quieter life on road trips Phenergan should not be used on children.
It may also be used for sedating people who are agitated or anxious. Phenergan (promethazine) is an antiemetic drug used for vomiting as well as an antihistamine (allergy pill) and a sedative (sleeping pill). It is available by mouth as a syrup, as a rectal suppository, or by injection into a muscle Common side effects include confusion and sleepiness …for children for POV prophylaxis. Promethazine should not be used in children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. Phenergan works as an phenergan sedative antihistamine, antiemetic, and sedative. Therapeutic Effects:PONV prophylaxis, antiemetic, antipsychotic, antihistamine, anticholinergic, sedation Anesthesia Implications Primary use for this drug is as an antiemetic and PONV prophylaxis Reduces PONV when used prophylactically. It may help with some symptoms associated with the common cold. Phenergan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Learn the side effects, drug interactions, dosages, similarities and differences of both medications Sedation. Promethazine prevents opioid-induced nausea and helps alleviate some withdrawal symptoms. It is also used as a sedative or sleep aid. Do not take more than the recommended dose unless your Things to be careful of Phenergan is a known sedative and may cause drowsiness in some people and may affect your ability to drive and operate machines For children over 10 years and adults, Phenergan Tablets may be more convenient. Sedation is prominent and extrapyrami-dal effects are uncommon. Personally I like Phenergan for migraines, motion sickness, nausea, sedation, vomiting & with pain medications. Make sure you know how you react to Phenergan before you drive a car, operate machinery, or do anything else that could be dangerous if you are drowsy. This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. To which i will ask for a cheaper brand as Phenergan is by far the most expensive! It is available by mouth as a syrup, as a rectal suppository, or by injection into a muscle Common side effects include confusion and sleepiness Sedation: Oral, I.M., I.V., rectal: 12.5 to 50 mg/dose.-----Background information: Title: Action needed to prevent serious tissue injury with IV promethazine. as brand; see generic] allergic conditions [6.25-25 mg PO tid-qid prn]. There is a high rate of therapeutic failure as well as a high rate of serious adverse reactions, including respiratory depression and death, associated with its use. Promethazine should not be used in children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. The sedation effects of alcohol may be increased. Promethazine may increase, prolong or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced. Children 2-5 years: Three or four 5ml spoonfuls as a single dose at night time; Children 5-10 years: Four or five 5ml spoonfuls as a single dose at night time. Promethazine may also be used for purposes not listed in this medication guide Phenergan may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, seizure medications, antidepressants, anxiety medicines, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary. The purpose of this study was comparing the velocity and durability of sedation induced by the haloperidol, trifluoperazine, promethazine, and chlorpromazine in aggressive patients …for children for POV prophylaxis. Phenergan is the brand name of the drug promethazine which is used as an antihistamine, sedative, and anti-nausea medication. Narcotics are usually injected into a vein (IV) or muscle. Promethazine has a variety of applications and has been used as an antiallergic, a sedative, and to treat motion sickness. Promethazine is well absorbed from the gastrointestinal tract. There are. Severe Interactions. Many times you can decrease the amount of pain medication given.. In order to relieve allergy symptoms such as a runny nose, watery eyes, red eyes, or to prevent motion sickness, your doctor may prescribe you this medication Promethazine (Phenergan) has been available since 1951 and although it has long been utilized as a sedative agent, it is a phenothiazine as well as an antihistamine. Warning:. We always draw up 50mg of Demerol and 5mg of Versed to start. Children younger than 2 years of age—Use and dose must be determined by your doctor. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long. Promethazine Facts. Dose dependent sedation, anticholinergic effects and orthostatic hypotension.